This might happen if the tumour does not have much of a blood supply and very little of the drug, which is delivered through the bloodstream, can get in. Los Angeles: Scientists have engineered novel proteins that work like 'guided missiles' which seek out cancer cells and deliver chemotherapy drugs to treat hard-to-reach tumours without harming healthy cells.The researchers are still exploring which of the two approaches will be most effective."Antibodies can be limited for treating solid tumours because they are too big to penetrate well.Although the two techniques are conceptually similar, the specialised protein has the potential advantage of being able to pass through the barrier that protects the brain, thereby being able to treat brain tumours.A dose high enough to infiltrate the tumour could be deadly to other cells in the body.The Aluminum Lip Gloss Tubes factory findings were published in the journals Molecular Cancer Therapeutics and Angewandte Chemie.Some recently approved therapies get around this problem using antibodies to deliver a drug directly to tumours, bypassing healthy cells and possibly overcoming some of the uglier aspects of cancer chemotherapy. The idea is that a smaller molecule could diffuse into the tumour better," Ms Cochran said..It is also smaller than the antibody and might be able to reach dense tumours with little blood supply.Although chemotherapy drugs do often effectively kill cancer cells, they also damage other quickly dividing cells in the body, causing side effects ranging from cosmetic, like hair loss, to disabling.Sometimes, the drug dose needed to kill a tumour may be more than what a person's body can handle.Now Jennifer Cochran, associate professor at Stanford University in the US, has built on this antibody approach using an engineered protein rather than an antibody to direct the drug to the tumour.A dose high enough to infiltrate the tumour could be deadly to other cells in the body.

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It has also appointed well-known lawyer Ujjwal Nikam as special public prosecutor in the case.The probable cause of death was “septicemic shock”, the bulletin added.Nagrale and the woman were friends till two years ago when she severed ties with him due to his “irrational behaviour”, the police earlier said.Home Minister Deshmukh visited the hospital on Tuesday and announced that the accused&eyeliner cases wholesale39;s trial would be fast-tracked.She was undergoing treatment at the Orange City Hospital & Research Centre here, located around 75 km from Wardha.According to the victim's relatives, Nagrale, who was arrested within hours of the incident on February 3, had been harassing her for quite some time.55 am today,” Hinganghat's police inspector Satyaveer Bandiwar said.“Around 6.“Doctors at the hospital declared her dead at 6.The woman sustained deep burn injuries on scalp, face, right upper limb, left hand, upper back, neck and eyes along with severe inhalational injuries, the hospital said in a medical bulletin on Monday.Heavy security was deployed in Hinganghat to avoid any law and order problem following her death, the police said.A special team led by Deputy Superintendent of Police # Trupti Jadhav will probe the case, the Wardha Police said last week.The woman's parents and uncle were kept informed about her deteriorating health condition and death, the hospital said, adding that the body was later handed over to police for postmortem and other formalities.Several locals, mostly women and college students, took out a march in Wardha city last Thursday, demanding death penalty for the accused.After the woman's condition deteriorated, the hospital informed about her critical status to Maharashtra Home Minister Anil Deshmukh, Wardha Guardian Minister Sunil Kedar, Nagpur Divisional Commissioner Sanjeev Kumar, Police Commissioner Bhushan Kumar Upadhyay, Wardha Collector Vivek Bhimanwar and Wardha Superintendent of Police Basavraj Teli.

As part of immediate resuscitation measures, medicines were escalated to maintain the blood pressure and all feasible steps were taken to improve the oxygen levels in blood, but the patient remained “extremely critical”, it said.During her treatment, she underwent tracheostomy , burn dressings, debridement and escharotomies, the hospital informed.Around 4 am onMonday,her oxygen levels deteriorated inspite of ventilator support, coupled with decreasing urine output and reduction in blood pressure, the hospital said.Ankita Pisudde, resident of Hinganghat town in Wardha, had been critical after sustaining 35 to 40 per cent “grade III” burns on February 3 when she was set afire allegedly by one Vikesh Nagrale while she was on way to her college, they said.30 am, she had bradycardia and inspite of prolonged cardiopulmonary resuscitation, the patient could not be revived and was declared dead at 6.55 am,” it said.The state government last week flew Navi Mumbai-based National Burns Centre director Sunil Keswani to Nagpur to supervise the woman's treatment.Debridement is a medical procedure to remove dead, damaged or infected tissue, while escharotomy is a surgical procedure used to treat full-thickness circumferential burns.She died of “septicemic shock” after suffering from deep dermal burns along with severe inhalational injuries, respiratory distress and related complications, it said..A 25-year-old woman lecturer who was set ablaze by a stalker in Maharashtra's Wardha district last week died while undergoing treatment at a hospital here on Monday morning, officials said.

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Agriculture remains the single largest consumer of water.Nevertheless, the water crisis cannot just be looked at from a technological perspective.Groundwater is India’s lifeline, with more than 22 million wells and borewells and over 250 BCM of groundwater being extracted annually.Let’s begin with some statistics. Chennai already has four such plants.Technology can not only help identify and China aluminum mascara case wholesale map aquifers and sub-aquifers but also develop a sustainable way of replenishing and reusing of rainwater and groundwater.Policies like metering in flats or wastewater treatment plants for residential apartments will give innovators, start-ups and existing players a market to develop and refine their ideas. Significant improvements will be needed in order to shift to pipe-based network distribution systems controlled by SCADA for increasing the irrigation efficiency of our dams. Nevertheless, increasing population has reduced per capita availability to around 1,431 cubic metres per person, below the 1,700 cubic metres per person ‘water stress’ defined by Malin Falkenmark.Precision technologies such as drip irrigation, micro-sprinklers and poly-houses not only help in soil management, crop development and management, but such technological innovations have the largest capacity to save water.

Leak detection equipment to identify and plug leaks, which are easy to use and accurate, will become necessary where 50 per cent of the water or more are lost during the distribution process. Low cost soil sensors to assist farmers in irrigation schedules, efficient pond lining material for farm ponds, and drips that require less cleaning should see progress.All technological interventions need a strong policy and regulatory framework. Transport and treatment of this sludge will become important for sanitation management across India. Meanwhile, the avaerage water flow in our river basins, as assessed by the Central Water Commission, stands at 1913. There is also a need to incorporate institutional, financial and ecological perspectives. The total average precipitation availability in India has remained broadly constant at around 3,880 billion cubic metres.Desalination plants will come up in more numbers in coastal cities but they need to be adapted to the local conditions. In future, it should be dynamically modelled at a river basin and sub-basin level to help manage water for ecological, social and economic purpose. This has exhausted groundwater in many parts of India.. Thus, a holistic approach aided by technology can pay rich dividends. Plugging water leaks will bring enormous benefits to the system.Small scale wastewater treatment plants that can recycle water to drinking water quality to large scale ones that also recover energy and nutrients will need to be developed.Faecal sludge management will need special focus.

Many have ascribed the success of the green revolution in terms of high yield of wheat and rice to the tube-wells and motors that supplied the water for the HYV varieties. SCADA systems, which can manage water systems and pressure optimisation for 24/7 water supply in our cities, will call for technological interventions. The advent of the hard rock drilling rigs in the 1960's and 1970's unleashed the groundwater revolution.So then, where can technological interpretations help? Remote sensing, hydrological flow measurement and rainfall data has helped the CWC to come out with an excellent report assessing the water flows.60 Billion Cubic Metres. Canal irrigation systems suffer from lack of efficiency, with tail end canals bearing the brunt of water shortage. Dynamic flow modelling and tracking of rivers will also help in reservoir management and flood management. Products that are affordable and efficient are still needed. The ability of technology to dig deeper has meant that borewells now draw fossil water from as much as 500 metres below the earth.In urban areas, technological innovation like easy to measure water meters will need to become the norm for every flat and building in the city.

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Japan is expected to take a decision on a linear collider in March, which could play into a potential choice by European countries in 2020 about whether to back the FCC or another proposal for CERN, the Compact Linear Collider.But the decision on whether to go ahead with the FCC - incurring an initial 9 billion euro bill for participating governments plus a later China Aluminum Lip Gloss Tubes wholesale 15 billion euro upgrade - is effectively part of an international race to host the LHC’s successor, with China, Japan, the United States and Europe all interested.But science mega-projects attract talent and can generate unforeseen spin-offs - including the invention of the World Wide Web at CERN, which has become a global centre for physicists, despite the high cost of living around Geneva.“Any big machine for the future will be a global machine,” said Arnaud Marsollier, head of media relations at CERN.The discovery of the Higgs boson in 2012 earned Peter Higgs and Francois Englert the 2013 Nobel prize.

The FCC, or Future Circular Collider, proposed by more than 150 universities and science institutes, would be a huge tubular circuit almost four times as long, with 10 times more power than the LHC at CERN, the European Centre for Nuclear Physics.“No one expects to have two 100-km colliders built in the next 20 years, so if one is built in China, maybe Europe will do something else.The existing collider , which started up in 2008, smashes protons together in a 27-km circuit beneath the Swiss-French border.A proposed 100-km particle accelerator under Geneva has joined an international quest to develop the successor to the Large Hadron Collider to help unlock humankind’s knowledge of matter.For physicists, the location may be less important than the science opportunities on offered by a new collider, allowing them to peer into the debris left when subatomic particles smash together and shatter into even smaller pieces, some of which may answer fundamental questions about the universe.

The proposal came out of the European strategy for particle physics, which recommended that design and feasibility studies be conducted in order for Europe “to be in a position to propose an ambitious post-LHC accelerator project at CERN by the time of the next strategy update”.China has floated plans for its own 100-km collider, but has not yet confirmed it will go ahead. It helped scientists discover the long-sought Higgs boson — a particle that supplied the missing piece of the standard model of physics by explaining why objects have mass.”The LHC is expected to keep running until around 2036-2040, by which time it will have done its job collecting data, but it might also be possible to upgrade it by increasing the energy of collisions, which would require major investment. They had predicted half a century earlier that it would one day be discovered.

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